Alpha-Pinene's Effects and Benefits
• Increased focus
• Increased happiness and creativity
• Bronchodilator (helps improve airflow to lungs)
With acute pancreatitis, alpha-pinene treatment reduced histological damage and myeloperoxidase activity in the pancreas and lungs. Furthermore, alpha-pinene pretreatment reduced the production of pancreatic tumor necrosis factor (TNF)-alpha, interleukin (IL)- 1beta, and IL-6 during acute pancreatitis. In vitro, alpha-pinene inhibited cerulein- induced cell death and cytokine production in isolated cerulein-treated pancreatic acinar cells. This could point to alpha-pinene possibly having beneficial effects with pancreatic cancer and maybe diabetes. It has been shown that alpha pinene has anti-inflammatory effects in human chondrocytes, thus exhibiting potential antiosteoarthritic activity. + alpha pinene was shown to inhibit the interleukin -1beta- induced inflammatory and catabolic pathways, nuclear factor kappa-light-chain-enhancer of activated B cells and c- Jun N-terminal kinases activation, and the expressionof the inflammatory (iNOS) and catabolic (MMP-1 and -13) genes.
Protective effects of alpha-pinene in mice with cerulein-induced acute pancreatitis
Anti-inflammatory and Chondroprotective Activity of (+)-?-Pinene: Structural and Enantiomeric Selectivity
As tested through solid medium diffusion procedure, pinene exhibited toxic effects against Staphylococcus aureus, S. epidermidis, Streptococcus pneumoniae and S. pyogene Inhibitory effect of α-pinene, α-pinene and eugenol on the growth of potential infectious endocarditis causing Gram-positive bacteria
Comparative Anti-Infectious Bronchitis Virus (IBV) Activity of (-)-Pinene: Effect on Nucleocapsid (N) Protein
Mice placed in an environment enriched with a-pinene demonstrated reduced melanoma growth, and tumor volume of the mice was about 40% smaller than that in the control mice. In another study, alpha-pinene was identified as an active anti-proliferative compound on liver cancer BEL-7402 cells using the MTT assay. Alpha-pinene inhibited BEL-7402 cells by arresting cell growth in the G2/M phase of the cell cycle, downregulating Cdc25C mRNA and protein expression, and reducing cycle dependence on kinase 1(CDK1) activity.
Fragrant environment with α-pinene decreases tumor growth in mice
Inhibitory Effects of α-Pinene on Hepatoma Carcinoma Cell Proliferation
Alpha pinene has been shown to be a uncompetitive reversible inhibitor of red blood cell acetylcholinesterase in vitro. The essential oil of sage having, camphor, 1,8-cineole, bornyl acetate, alpha pinene and several other terpenes in much smaller concentrations were exposed to human cells. Since many memory-enhancing and dementia drugs are based on inhibiting cholinesterase to enhance cholinergic activity, it is thought that alpha-pinene may act as an effective supplement for such conditions.