Beta-Caryophyllene - Research

Beta-Caryophyllene's Effects and Benefits
• Anti-anxiety
• Anti-depressant 
• Reduce feelings of stress and tension
• Anti-inflammatory
• Good for Arthritis

Beta-Caryophyllene (β-Caryophyllene) is a sesquiterpene found in many plants such as Thai basils, cloves, cinnamon leaves and black pepper, and in minor quantities in lavender. It's aroma has been described as peppery, woody and/or spicy. Caryophyllene is the only terpene known to interact with the endocannabinoid system (CB2). Studies show β-caryophyllene holds promise in cancer treatment plans. 
The Horvth et al study suggests β-caryophyllene, through a CB2 receptor dependent pathway, may be an excellent therapeutic agent to prevent nephrotoxicity (poisonous effect on the kidneys) caused by anti-cancer chemotherapy drugs such as cisplatin. 
The Jeena, Liju et al study investigated the chemical composition of essential oil isolated from black pepper, of which caryophyllene is a main constituent, and studied its pharmacological properties. Black pepper oil was found to possess antioxidant, anti- inflammatory and antinociceptive properties. This suggests that beta-caryophyllene may be useful in treating a number of medical issues such as arthritis and neuropathy pain. Evidence has come to light that the CB2 receptor is of particular interest in anxiety and depressive disorders. Few systematic studies on lab animals had occurred, so scientists set out to experiment the effects of the caryophyllene agonist in the CB2 receptors of animals subjected to stress to measure the antidepressant and anxiolytic effects of the terpene. They found β-caryophyllene to be highly effective in reducing the stress and anxiety exhibited by the animals while undergoing their various stress tests. These promising indications show that β-caryophyllene may prove useful in treating human mood disorders in the future. 


The analgesic effects of beta-caryophyllene were evaluated in the rabbit conjunctival reflex test and in a rat phrenic nerve-hemidiaphragm preparation. Beta-caryophyllene attenuated thermal hyperalgesia and mechanical allodynia, and reduced spinal neuroinflammation. Also there were no signs of tolerance to the anti-hyperalgesic effects of BCP after prolonged treatment. 
Local anaesthetic activity of β-caryophyllene 
The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain 

Beta-caryophyllene was demonstrated to have a high inhibitory capacity on lipid peroxidation and showed high scavenging activities against hydroxyl radicals and the superoxide anion. 
The antioxidant effect of β-caryophyllene protects rat liver from carbon tetrachloride- induced fibrosis by inhibiting hepatic stellate cell activation 

In kidney cells, beta-caryophyllene successfully ameliorated cisplatin-induced kidney dysfunction, morphological damage, and renal inflammatory response. The effect of the compound was also correlated to mitigate oxidative and nutritive stress. 
?-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor- dependent manner 

Caryophyllene was indicated to significantly inhibit gastric mucosal injuries induced by necrotizing agents, yet barely affects the secretion of gastric acid and pepsin. Caryophyllene produced anti-inflammatory effects, without indication of gastric mucosal damage typical of non-steroidal anti-inflammatory agents like aspirin and ibuprofen.
β-Caryophyllene Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice through CB2 Receptor Activation and PPAR? Pathway