Linalool - Research

Linalool's Effect and Benefits
• Anxiety relief
• Anti-depressant
• Decreased Stress
• Calming and relaxing
• Anti-acne
• Anti-epileptic

Linalool is a non-cyclic monoterpene and has been described as having floral and lavender undertones. Linalool is a naturally occurring terpene found in many flowers and spices including lavender and coriander. Varieties of essential oils high in linalool promote calming and relaxing effects. Linalool lessens the anxious emotions, thus making it helpful in the treatment of both psychosis and anxiety. 
Humans have inhaled the scent of certain plants, including many containing linalool, since ancient times to help lower stress levels, fight inflammation, and combat depression. Linalool has been the subject of many studies, including a recent one in which scientists allowed lab rats to inhale linalool while exposing them to stressful conditions. It was reported that linalool returned elevated stress levels in the immune system to near-normal conditions. Therefore when applied to human allows for a less stressful quality of life. Linalool works synergistically when in combination with pinene, creating an even more uplifting anti-depressed state of mind. Linalool has also been found to be a major contributor to the anti-epileptic effect of cannabis. 


Linalool was able to reduce carrageenin-induced edema in rats, a classic model of inflammation. It's acetate version was noted to have the same effect as well 
Anti-inflammatory activity of linalool and linalyl acetate constituents of essential oils 

In mice exposed to acetic acid-induced writhing response and the hot plate test, linalool was able to act on the opioidergic and cholinergic systems in a manner to prevent neural networks from transmitting the signal of pain. 
Linalool produces antinociception in two experimental models of pain 

Linalool was eluted to possess pharmacological activity close to that of diazepam. In a PTZ model, PIC seizure mode, and tonic convulsions induced by transcorneal electroshock, linalool therapeutically decreased the convulsion time in mice Anticonvulsant activity of the linalool enantiomers and racemate: investigation of chiral influence. 

In an elevated plus maze test, linalool indicated to modulate motor movements and locomotion. At a high enough dose, linalool was able to make the mice go to sleep. Investigation of the anxiolytic effects of linalool, a lavender extract, in the male Sprague-Dawley rat. 

Linalool was shown to possess anxiolytic properties without any side effects, showing promising potential use in treatment of anxiety disorders. Linalool was evaluated on 4-week ICR mice using an open field test, a light-dark test and an elevated plus maze test. The measurements of monoamines in the brain showed decreased serotonin, dopamine, and norepinephrine, which is commonly seen in animal models exhibiting anxiolytic effects. Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice