Myrcene - Research

Myrcene's Effects and Benefits
• Anti-inflammatory
• Analgesic (pain relief)
• Muscle relaxant
• Antibiotic
• Sedative
• Anti-mutagenic

Myrcene is a natural organic compound found in the essential oils of several plants that is classified as a monoterpene. Myrcene is a recognized sedative, as part of hops preparations employed to aid sleep in Germany. Furthermore, myrcene acts as a muscle relaxant and can potentiate barbiturate sleep time at high doses. Myrcene can be used to promote sedation, muscle relaxation, restful sleeping. Myrcene displays powerful pain-relieving properties, along with anti-inflammatory and antibacterial benefits. This has lead to the suggestion that Myrcene may have the potential to act as an alternate to some aspirin-like pharmaceuticals. Myrcene has an amazing property to lower the resistance across the blood brain barrier, allowing itself and many other essential oils to flow into the brain much faster. 



Oral administration of myrcene in rats was concluded to produce a dose-dependent pain relief for the hyperalgesia induced by subplantar injections of either carrageenin or prostaglandin E2, but did not affect that induced by dibutyryl cyclic AMP. These results indicated a peripheral site of action. In contrast to the central analgesic effect of morphine, myrcene did not cause tolerance on repeated dosing in rats. Myrcene shows promise as a lead for the development of new peripheral pain killers with a different method of action than aspirin-like drugs. 
Myrcene mimics the peripheral analgesic activity of lemongrass tea 

Myrcene was explored as a sedative in the mouse model. Muscle relaxation was seen as observed through the rota rod test. In addition there was an increase in sleeping time by 2.6x. 
Myrcene mimics the peripheral analgesic activity of lemongrass tea 

Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes 
from Lippia alba (Mill.) n.e. Brown.

Myrcene was eluted to block the metabolic activation of some promutagens (e.g., cyclophosphamide and aflatoxin B1) in in vitro genotoxicity assays. The effects of myrcene was evaluated through the activity of liver microsomes. A concentration-dependent competitive inhibition was observed for pentoxyresorufin -O-depenthylase activity, a selective marker for a cytochrome p450. The potent inhibitory effects on the cytochrome p450 suggest that myrcene, could also interfere with the metabolism of xenobiotics, which are substrates for this isoenzyme In vitro inhibition of CYP2B1 monooxygenase by beta-myrcene and other monoterpenoid compounds